Recent Advances in Severe Asthma

Recent advances in asthma.

There have recently been important advances in our understanding of asthma mechanisms and treatment. Asthma is now recognized as a disease of the airways which involves a special type of inflammation, characterized by the presence of activated mast cells, eosinophils and T-lymphocytes. There has been a growing recognition that chronic rather than acute inflammatory events are more relevant to u...

Recent advances in asthma genetics

There are over 100 genes that have been reported to be associated with asthma or related phenotypes. In 2006-2007 alone there were 53 novel candidate gene associations reported in the literature. Replication of genetic associations and demonstration of a functional mechanism for the associated variants are needed to confirm an asthma susceptibility gene. For most of the candidate genes there is...

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Recent advances in the treatment of asthma.

Recent advances in understanding and managing asthma

This review highlights the important articles published in the area of asthma research from January 2015 to July 2016. In basic science, significant advances have been made in understanding the link between the innate immune response and type II acquired immune responses in asthma and the role of the airway epithelium. Novel information continues to emerge with regard to the pathogenesis and he...